Antineutrophil cytoplasmic antibodies to proteinase 3 in Wegener's granulomatosis: Epitope analysis using synthetic peptides
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چکیده
منابع مشابه
Antineutrophil Cytoplasmic Antibodies in Patients with Pulmonary Tuberculosis
Background: Mycobacterium tuberculosis is a major cause of mortality and morbidity worldwide. Infection with this bacterium is known to induce the development of autoantibodies of which a few are also known to be diagnostic markers for some other diseases. Antineutrophil Cytoplasmic Antibodies (ANCA's) are among those autoantibodies used in clinical setting for diagnosing systemic vasculitic sy...
متن کاملThe binding of proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) varies in different ELISAs.
BACKGROUND The demonstration of proteinase 3 specific antineutrophil cytoplasmic antibodies (PR3-ANCA), and the estimation of antibody values are useful in the diagnosis and management of patients with Wegener's granulomatosis (WG). However, external quality assessment programmes suggest that PR3-ANCA binding varies in different assays. AIM To demonstrate variations in PR3-ANCA binding in dif...
متن کاملMonitoring proteinase 3 antineutrophil cytoplasmic antibodies for detection of relapses in small vessel vasculitis.
The clinical usefulness of antineutrophil cytoplasmic antibodies (ANCAs) in the monitoring of patients treated for small vessel vasculitis is debated. A capture enzyme-linked immunosorbent assay (ELISA) based on anti-proteinase 3 (anti-PR3) monoclonal antibody 4A3 has previously been proven to be superior to indirect immunofluorescence (IIF) and standard ELISA for the diagnosis of vasculitis. T...
متن کاملUlcerative colitis with positivity for proteinase 3-antineutrophil cytoplasmic antibody.
ANCA) and the perinuclear (P-ANCA). CANCA appears as a granular, diffuse cytoplasmic fluorescence, often with accentuated fluorescence around the nuclear lobes, and typical P-ANCA reactivity is Dear Sir, A 33-year-old woman was admitted to our hospital with cough and fever (over 39.0 ° C). About 1 month prior to the current admission, she had presented with fever (over 39.0 ° C), diarrhea and b...
متن کاملAntineutrophil cytoplasmic antibodies.
Antineutrophil cytoplasmic antibodies (ANCA) are predominantly IgG autoantibodies directed against constituents of primary granules of neutrophils and monocytes lysosomes. Although several antigenic targets have been identified, those ANCA directed to proteinase 3 or myeloperoxidase are clinically relevant, whereas the importance of other ANCA remains unknown. Both are strongly associated with ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2001
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2001.00475.x